Listing 10.06 · Congenital disorders

Down syndrome (non-mosaic)

To be approved under this listing, a claim must meet any one of the criteria below — and the medical records have to prove it.

  1. A

    Documentation of non-mosaic Down syndrome by laboratory karyotype analysis OR by physician statement supported by evidence of clinical features.

    In plain terms: Has Down syndrome been confirmed by genetic testing or by a physician statement?

    Evidence required:Genetic testTreating physician report

Note · Non-mosaic Down syndrome is a Compassionate Allowance condition; the listing is met on documented diagnosis.

Read the official SSA text for Listing 10.06

Free case review

Not sure your records show this?

Meeting a listing comes down to what’s documented in your file. A disability attorney can review your records and tell you what’s missing — no cost to talk, and most only get paid if you win.

Estimate the odds

Historical approval rates for a claim like this — by state, age, and stage.

Approval odds by condition

How claims for this body system fare through the process.

Source: SSA Listing of Impairments (Blue Book), 20 CFR Part 404, Subpart P, Appendix 1 · Updated 2026-06-18. Criteria paraphrased for readability; see the official SSA text linked above. Not legal or medical advice — whether a specific medical record meets Listing 10.06 is an individualized judgment SSA makes on the evidence.