Listing 10.06 · Congenital disorders
Down syndrome (non-mosaic)
To be approved under this listing, a claim must meet any one of the criteria below — and the medical records have to prove it.
- A
Documentation of non-mosaic Down syndrome by laboratory karyotype analysis OR by physician statement supported by evidence of clinical features.
In plain terms: Has Down syndrome been confirmed by genetic testing or by a physician statement?
Evidence required:Genetic testTreating physician report
Note · Non-mosaic Down syndrome is a Compassionate Allowance condition; the listing is met on documented diagnosis.
Estimate the odds
Historical approval rates for a claim like this — by state, age, and stage.
Approval odds by condition
How claims for this body system fare through the process.
Source: SSA Listing of Impairments (Blue Book), 20 CFR Part 404, Subpart P, Appendix 1 · Updated 2026-07-31. Criteria paraphrased for readability; see the official SSA text linked above. Not legal or medical advice — whether a specific medical record meets Listing 10.06 is an individualized judgment SSA makes on the evidence.